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Most patients report reduced appetite and food cravings within 37 days of their first dose, a sign that the medication is working at the cellular level

Consistent with this idea, semaglutide-mediated enhancement of energy expenditure has been described in obese mice [48]

The effects of semaglutide on the average annual change in eGFR in FLOW, SELECT and SUSTAIN-6 are shown in Figure 3

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It mimics the action of endogenous GLP-1, a hormone released by the intestines in response to food intake