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This is a small optimization, but experienced users report noticeably better absorption compared to either dehydrated or immediately-post-drinking administration

They are widely used for obesity treatment as they suppress appetite, slow gastric emptying, and reduce food cravings

doi:10.1038/ajg.2012.373

Contrave (naltrexone/bupropion) has demonstrated effectiveness for long-term weight loss when used in conjunction with a reduced-calorie diet and regular exercise
They are regulated by their states and must follow quality-control procedures

Rush EC, Yan MR
