glp-1 agonist gastroparesis Gastrointestinal effect and adverse effects of receptor Our Pipeline - Neurogastrx, Inc.

GLP-1 improves mitochondrial function via regulation of autophagy, inhibits myocardial apoptosis, and optimizes cardiac energy metabolism [41, 42]

14,15 Another meta-analysis of 93 clinical trials showed that GLP-1 RAs increased the risk of early-stage DR compared with placebo, with this effect being driven by albiglutide in particular

However, this evidence is limited, inconsistent, and does not demonstrate clinically significant effects comparable to prescription GLP-1 agonists

Dulaglutide was linked to systemic hypersensitivity events in 0.5% of patients in phase II and III trials [103]

Consequently, it is essential to prioritize shared decision-making and individualized risk-benefit assessments for prescribing GLP-1 RAs, while avoiding misuse with off-label indications

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