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The long elimination half-life of 25-68 hours further supports convenient once-daily dosing

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Renal Function : Both Januvia and metformin are primarily excreted by the kidneys, so their use may require adjustments in patients with impaired renal function

Similar content being viewed by others Introduction In healthy individuals, the maintenance of plasma glucose homeostasis is obtained by finely tuned interactions of hormones, metabolic processes, energy uptake and expenditure

Science 348 , 453457 (2015)

GLP-1 drugs Bariatric surgery remains the most effective option for long-term weight loss in appropriately selected patients