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Cresci B, Cosentino C, Monami M, Mannucci E (2020) Metabolic surgery for the treatment of type 2 diabetes: a network meta-analysis of randomized controlled trials

Clinical trials have shown that anti-obesity medications are effective

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Within the CNS, hindbrain GLP1 neurons project to numerous brain regions relevant to metabolic regulation in mice (Figure 1) (Burcelin et al., 2009

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And because obesity itself is a known driver of GI dysfunction, every data point carries an asterisk: Is this the drug or the disease its treating