can semaglutide negativly impact circulation (#ozempic / #wegovy) increased walking distance in patients with symptomatic peripheral artery disease and type 2 #diabetes.Peripheral artery disease is a debilitating atherosclerotic The Cardioprotective Effects of Semaglutide

Clopidogrel is inactive when administered It must be metabolized in the liver (mainly by CYP2C19) into an active thiol metabolite The active metabolite then produces the antiplatelet effect Mechanism of action The active metabolite irreversibly inhibits the P2Y ADP receptor on platelets This prevents platelet activation and aggregation Clinical uses Prevention of ischemic stroke Prevention of myocardial infarction Postcoronary stent placement Alternative to aspirin in aspirin intolerance Delayed onset compared to aspirin (because activation is required) Reduced efficacy in patients with CYP2C19 deficiency or when taken with CYP2C19 inhibitors (e.g., omeprazole) Effect lasts for the life of the platelet (710 days) Clopidogrel = Prodrug Aspirin = Active drug Prasugrel, Ticagrelor antiplatelets (note: ticagrelor is NOT a prodrug) To view or add a comment, sign in With respect to gliptins and Parkinson's disease, which statement is false

This area may be easier to access with help from another person, as reaching the correct area yourself can be difficult

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Pre-existing renal impairment is a critical factor in prescribing decisions

Progesterone causes water retention during the luteal phase and early menstruation

confirm volume with prescriber instructions