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Description
It can start with tolerance , which is needing an increased dose for the same effect over time

Garner, Dena P

But for me

The putative satiety effect of a compound would be seen as an effect on satiety VAS during the breakfast meal and on the spontaneous caloric intake at the lunch meal

But the trade-off is better adherence: when patients tolerate their medication, they stick with it

Guentsch A, Preshaw PM, Bremer-Streck S, Klinger G, Glockmann E, Sigusch BW