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Patients already taking statins should continue these medications when starting Saxenda, as the weight loss achieved may complement but not replace the lipid-lowering effects of statins

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Even though higher doses of oral semaglutide (25 mg and 50 mg) can achieve similar HbA 1c and weight reductions to orforglipron, the convenience of unrestricted daily orforglipron dosing means this is likely to be more attractive to people requesting an oral drug, depending on whether cardiovascular benefits are observed in the outcomes study

This effect occurs through the JNK/NF-B signaling pathway [241]