do the glp-1 patches really work GLP 1 Work? Evidence, Safety, & What Actually Helps GLP-1 Patches vs. GLP-1 Injections:

doi: 10.1016/j.molmet.2021.101181 [DOI] [PMC free article] [PubMed] [Google Scholar] 109

Unintentional weight loss exceeding expected therapeutic goals, or inability to maintain adequate nutritional intake, requires assessment for excessive medication effect or other underlying conditions

2015Caveolins in cardioprotection - translatability and mechanisms

Mendonca, L., Moura, H., Chaves, P

Phentermine increases heart rate and blood pressure through sympathomimetic activity, while GLP-1 agonists have shown mixed cardiovascular effectsbenefits in diabetic populations but potential concerns in certain patient subgroups, particularly those with a history of thyroid cancer or multiple endocrine neoplasia

This definition takes pharmacokinetics into account in addition to injection frequency [13]