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doi: 10.2337/diabetes.53.4.955

The pivotal role of high glucose-induced overexpression of PKC in the appearance of glucagon-like peptide-1 resistance in endothelial cells

BMJ 374, n1682

Among adaptations to a dry environment is a slow metabolism, allowing them to use less than half the amount of energy expected for lizards of their size

Conversely, stages of a womans life, such as adolescence, perimenopause and menopause, that are associated with reduced estradiol, are also associated with weight gain

Phase one is 9%, phase two is 12%, phase three is 29% with the rest of it coming from that early basic research, drug discovery, preclinical studies, and a little bit later with the regulatory review
