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- Oral semaglutide (only FDA approved for diabetes treatment) and injectable liraglutide, (FDA approved for obesity treatment as Saxenda,) lead to relatively modest amount of weight loss

These cardiovascular biology studies have established Semaglutide as the reference long-acting GLP-1R agonist for studying the cardiovascular pharmacology of chronic incretin receptor activation and the translational mechanistic basis of GLP-1R agonist cardiovascular outcome benefits

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Clinical data from the STEP trials (semaglutide's landmark efficacy studies) showed that participants maintaining semaglutide treatment reported improved physical activity levels and exercise capacity after the first 36 months