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Some patients and clinicians prematurely conclude the medication is ineffective before reaching therapeutic doses of 10-15 mg weekly

The NIH pharmacology review on semaglutide safety data shows that FDA-approved products are subject to strict clinical trials and manufacturing controls

Manufacturers may petition FDA for inclusion on the Green List, but this requires providing robust evidence of compliance with cGMP standards, including Certificates of Analysis, process validation, and detailed manufacturing records

It also compounds the risk of functional decline and bone density loss, which is the opposite of what a longevity-focused patient is working toward

Once you reach a point where you no longer want to lose weight, its important to talk to your GP or pharmacist about the next steps

GLP-1 tends to decrease your hunger and appetite and increase satiety (helping you feel fuller)