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In a phase I clinical trial, patients who were overweight or obese were able to reduce their body weight by 4.8% (3 mg dosage), 6.4% (4.5 mg), and 6.0% (6 mg) after receiving a once-weekly dose of mazdutide [51]

It may be useful in patients who have achieved their goal weight and are using lower doses to maintain their weight. However, early data and clinical experience suggest that it is an effective strategy, Orandi commented

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One such challenge is that GLP-1s are designed to be taken for the long-term, however, up to 68% of people have discontinued their treatment as soon as one year later

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