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Gastrointestinal side effects such as nausea, diarrhoea, or vomiting were the most common adverse events in the phase 2 program, and they occurred more frequently at higher doses

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Real-time quantitative polymerase chain reaction (RT-qPCR) was carried out in a LightCycler 480 detection system (Roche) using the LightCycler FastStart DNA Master plus SYBR Green I Kit (Roche)