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Both outcomes are clinically meaningful, but they illustrate why BMI at treatment initiation shapes expectations about results

Secondary outcomes included each of these events considered separately

The framework below provides guidance, though individual circumstances always require personalized medical evaluation

Fibrosis also improves with weight reduction, with 79.99 % or 10 % of weight reduction after 52 weeks of lifestyle intervention resulting in 50 % or 81 % of fibrosis regression, respectively, without any fibrosis worsening in adult patients with MASLD and baseline fibrosis on biopsy [39]