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Clin Med Insights Endocrinol Diabetes

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Adherence and Costs In manufacturer-sponsored trials of GLP-1s for obesity, reported adherence (sustained use) has ranged from 83% to 88% at 66-68 weeks

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Signs of Injection Site Complications and When to Seek Help Minor redness, slight swelling, and mild bruising are common and typically resolve within 48 to 72 hours without intervention

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Neither component interacts with GLP-1 receptors at all

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The SURPASS-4 clinical trial was a non-inferiority study comparing tirzepatide to insulin glargine where tirzepartide showed superior A1c and body weight reductions from baseline in adults with T2DM at increased CVD risk.[20] Also, tirzepatide reported a higher occurrence of individuals achieving an A1c below 7% compared to insulin glargine

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The Katsi et al

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