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Clin Med Insights Endocrinol Diabetes

Adherence and Costs In manufacturer-sponsored trials of GLP-1s for obesity, reported adherence (sustained use) has ranged from 83% to 88% at 66-68 weeks

Signs of Injection Site Complications and When to Seek Help Minor redness, slight swelling, and mild bruising are common and typically resolve within 48 to 72 hours without intervention

Neither component interacts with GLP-1 receptors at all

The SURPASS-4 clinical trial was a non-inferiority study comparing tirzepatide to insulin glargine where tirzepartide showed superior A1c and body weight reductions from baseline in adults with T2DM at increased CVD risk.[20] Also, tirzepatide reported a higher occurrence of individuals achieving an A1c below 7% compared to insulin glargine

The Katsi et al
