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Description
A phase 2, randomised, double-blind, placebo-controlled, dose-ranging study evaluating retatrutide was published in the New England Journal of Medicine (NEJM) in June 2023 (Jastreboff et al
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The compound combines balanced agonist activity across all three target receptors with structural modifications Aib substitutions and C20 fatty diacid acylation that extend half-life through albumin binding
In line with these findings, a previous trial found that once-weekly subcutaneous semaglutide did not affect exposure of ethinylestradiol and levonorgestrel to any clinically relevant degree, even though a 20% increase in levonorgestrel AUC was observed [9]
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The medication works best in patients with prediabetes or metabolic syndrome where insulin dysfunction drives weight gain
