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4) PEGylation modification: Increase the size of drug molecules and slow down enzyme degradation

Tirzepatide was developed as an oral or an injectable drug product

169 Ghrelin also mediates insulinostatic actions even though human beta-cells do not express any known receptors for ghrelin, but a recent study discovered that the ghrelin receptor is expressed solely by delta-cells, implying that ghrelin dampens insulin secretion by inducing somatostatin release