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GLP-1 helps smooth these spikes and dips by supporting better insulin release and lowering sugar output from the liver

However, as more people continue therapy for an extended period, a concerning pattern unfortunately emerges for many patients consistently

Reimbursement and formulary status for GLP-1 RAs depend on: clinical endpoints (A1c and weight loss thresholds), tolerability and discontinuation rates, and increasingly, cardiometabolic outcomes