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Gut 2009;58:990-7.ArticlePubMed 49

So far, the largest molecule known to cross the BBB through a nonsaturated mechanism (active transport or specific receptor-mediated pathways rather than passive diffusion) is CINC-1, a cytokine involved in regulating inflammation and immune responses, with a molecular weight of 7.8 kDa

The twin cycle hypothesis suggests that long-term excess calorie intake leads to triglyceride accumulation in the liver, impairing insulin function

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