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Together, these data suggested that activating GLP-1R alleviated glycolysis, at least partially by the suppression of PFKFB3-driven glycolysis, and attenuated lactate-mediated histone lactylation, which in turn suppressed the transcription of profibrotic genes in TGF-1 + IL-1-challenged fibroblasts

26 , 27202737.e5 (2019)

Tran N, Pham B, Le L
If a patient is on Fosamax and has difficulty maintaining upright sitting or standing for 30 minutes after morning medications due to their mobility limitations, this is a clinically relevant piece of information to discuss with them and, when appropriate, to flag with the medical team

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