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EClinicalMedicine 27:100538

GLP-1 has a short half-life of only two minutes, due to renal clearance and endogenous GLP-1 is degraded by the enzyme dipeptidyl peptidase IV (DPP-4) (2022)

Its becoming quite mainstream

What makes GLP-1 particularly effective is that it only stimulates insulin when blood glucose levels are elevated, reducing the risk of hypoglycemia (low blood sugar)

[5] While saffron extracts have been studied for various health benefits, Supresa is specifically optimized and standardized for appetite control

Frias JP, Nauck MA, Van J, Benson C, Bray R, Cui X, Milicevic Z, Urva S, Haupt A, Robins DA