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Description
Side Effects and Safety Considerations Like all prescription medications, GLP-1 therapies may cause side effects such as nausea, gastrointestinal discomfort, or reduced appetite during initial use
Continue scheduled follow-ups to review progress, discuss side effects, and align the plan with your goals

A separate class-level subgroup analysis excluding trials with study populations least comparable to SURPASS-CVOT, specifically ELIXA, which enrolled patients with recent acute coronary syndrome (within 180 days of medication initiation), and FLOW, a dedicated CKD outcomes trial

Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)
How tirzepatide works at microdose levels Understanding the mechanism helps explain why microdosing can produce benefits even at sub-therapeutic doses

Tirzepatide frequently causes nausea (12-22% of patients), diarrhea (12-16%), vomiting (6-10%), constipation (6-7%), and abdominal discomfort, particularly during dose escalation