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This unique mechanism has delivered some of the most dramatic results ever seen in obesity treatment, with participants in Phase 2 trials losing up to 24% of their body weight in under a year

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Some medications to watch out for include: Medications used to treat type 1 or type 2 diabetes, including insulin or sulfonylureas (such as Amaryl or Glucotrol XL) Tirzepatide causes a delay in gastric emptying, so it has the potential to impact the absorption of medications that are taken by mouth at the same time

In addition to these direct effects on the kidney and the heart, it is likely that GLP-1 regulates diuresis and natriuresis via neural mechanisms as well