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Some studies have suggested that the proliferation and apoptosis of granulosa cells (GCs) are the root causes of follicular development and atresia, with forkhead box protein O1 (FoxO1) playing an important role in promoting PCOS follicular atresia and GCs apoptosis (162, 163)

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Four more gliptins, namely teneligliptin, anagliptin, omarigliptin, and trelagliptin are only approved in the Japanese and Korean markets

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GLP-1 receptor activation can reduce neuroinflammation and oxidative stress, and restore insulin signaling, which may compensate for the dysfunctional dopaminergic neurotransmission and motor deficits associated with PD pathogenesis [74, 75]

2021 doi: 10.1172/JCI146353