glp-1 agonists reduce inflammation and Inflammation: How These Drugs Ease Arthritis Mechanisms by which GLP-1 agonists

52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

Polyethylene glycol (PEG) is a water-soluble inert polymer that reduces the renal clearance of the drug and prolongs the half-life, in addition to enhancing water solubility and preventing proteolysis

To do the math for you, thats about a fifth of their body weight = ~ 22 kg = almost 49 lbs

Approved by the U.S

May have higher risk of GI or metabolic side effects

Patients receiving semaglutide also achieved a whopping 12.5% reduction in their total body weight over the 72-week study period