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Key implications: Simplified administration may improve patient uptake Broader accessibility across diverse healthcare settings Reinforces the shift toward chronic disease models in obesity care As we move forward, the focus will not only be on efficacy but also on real-world implementation, cost considerations, and long-term outcomes

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Multiple randomized controlled trials and meta-analyses in patients with type 2 diabetes and obesity demonstrate that GLP-1RA therapy either preserves or modestly increases bone mineral density (BMD) at key skeletal sites lumbar spine and hip, GLP-1RAs also favorably modulate bone turnover markers, increasing bone formation markers (P1NP, osteocalcin, bone-specific alkaline phosphatase) and reducing bone resorption markers (-CTX), suggesting a net positive or neutral effect on bone remodeling