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The pathophysiology of diabetic nephropathy is mainly due to the enhanced glucose uptake in tubule cells via SGLT2 inducing oxidative stress, expression of inflammatory and fibrosis genes, and increased apoptosis (Figure 2) [85,86]

den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, et al

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