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What Is Leg Pain

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The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight

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They are not FDA-approved for Type 1 diabetes

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A few key players in the market are AstraZeneca

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However, a pharmacovigilance study using the WHO's global adverse drug reaction database found disproportionate reporting of eating disorder adverse events with all three major GLP-1 medications ( Nishida et al., Clinical Nutrition, 2025 )

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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (12, 46, 47)

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