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Orforglipron, Eli Lillys oral non-peptide GLP-1 agonist currently awaiting approval, is synthesized by conventional organic chemistry in a standard chemical reactor

The new study found that GLP-1 drugs appear to double the risk for developing neovascular age-related macular degeneration (nAMD), a condition that causes vision loss

One such study by McClean and colleagues [61] observed that liraglutide can cross the blood-brain barrier in substantial amounts and can prevent deficits in the water maze task performance and object recognition in AD model mice

[DOI] [PubMed] [Google Scholar] 64.Rivera F.B., Lumbang G.N.O., Gaid D.R.M., et al

Predominantly located in the ganglion cell layer of the retina with additional sparse expression detected in the inner nuclear layer and outer nuclear layer, GLP-1R was found to be expressed at high levels in the retina, even surpassing in tissues like the liver and bowel