who discovered glp 1 History of glucagon-like peptide-1 receptor agonists Scientists Who Pioneered GLP-1 Drugs

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Our findings are relevant to a previous network meta-analysis that evaluated multiple types of glucose lowering drugs in patients with type 2 diabetes with HbA 1c as the endpoint and concluded that GLP-1RAs were the most effective in lowering HbA 1c concentrations

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Most studies report the absence [[397], [398], [399]] or very restricted expression of the GLP-1 receptor in a small subset (10%) of -cells [395], and treatment of isolated rat -cells with GLP-1 enhances rather than inhibits the release of glucagon [[604], [605], [606]]