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The relatively high expression of GLP-1Rs in the hypothalamus supports their critical role in controlling feeding behaviour

For women planning pregnancy, discontinuation timing varies by medication: Semaglutide (Wegovy, Ozempic): Stop at least 2 months before planned conception Tirzepatide (Mounjaro): Follow SmPC guidance (typically around 1 month) Liraglutide (Saxenda): No fixed period is specified, but discontinue when planning pregnancy There are theoretical concerns related to these medications during pregnancy

The Week 12 Milestone The week 12 checkpoint deserves its own mention because the data at this point is highly predictive

If more than 5 days have passed, skip the missed dose and administer your next dose on the regularly scheduled day without doubling up

References Zepbound\u00AE is a registered trademark of Eli Lilly and Company

Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin as an Add-on to Metformin, Thiazolidinediones, or Both, in Patients With Type 2 Diabetes (SUSTAIN 2): A 56-Week, Double-Blind, Phase 3a, Randomised Trial