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Broader endocrine rewiring, including modulation of biomarkers linked to adipose regulation and insulin sensitivity, further underscores its potential in metabolic syndrome and cardiovascular risk research

Metformin-associated lactic acidosis (MALA) remains a theoretical concern in patients with renal impairment

Therefore, any relationship between GLP-1 therapy and muscle cramps is more likely to be indirect, mediated through secondary metabolic, nutritional, or fluid balance alterations rather than through direct receptor-mediated effects on muscle tissue

Recent studies in gastroenterology suggest that endoscopists should be prepared for a higher likelihood of incomplete procedures, longer procedure times, greater patient discomfort, and reduced tolerance when performing colonoscopy on obese individuals