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when were glp 1 agonists discovered Evolution of GLP-1 receptor (1906-2025): From discovery to JCI - Discovery, characterization, and
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Reviews in Endocrine and Metabolic Disorders, 15 (3), 197207

Florin Despa (Department of Pharmacology, University of Kentucky) for sharing valuable insights into the preclinical and clinical actions of amylin in both animal models and humans

PMID 27313432

347 This was achieved by decreasing the expression of proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8)
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes

We are starting to witness the fruits of that work with dozens of agents in development that will be more efficacious for obesity and its related complications
