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Gastroenterology 2024;167(2):402404.e3
The sensitivity analysis removing SURPASS J-mono [30] trial showed that statistical heterogeneity decreased from 95% to 0%, 97% to 90%, and 98% to 90%, respectively

But among those patients who are taking the drugs, we are seeing improvements in health

The patterns of relative activity among ACPC-containing analogues of GLP-1 and exendin-4 support the hypothesis that access to non-helical conformations near the agonist N-terminus is important for GLP-1R activation
GLP-1 medications have been studied in large clinical trials over multiple years and have a well-established safety profile when used under physician supervision