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These medications fall under a class known as glucagon-like-peptide-1 receptor agonists also known as GLP-1s

This systemic reach has led researchers to explore whether lower, sustained doses of GLP-1 RAs could maintain receptor activity sufficient to preserve metabolic and organ health without the adverse events often seen with aggressive dosing

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Understanding GLP-1based therapy mechanisms will require considering systemic versus local effects and distinguishing between immune and non-immune pathways

Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin hormone primarily produced by L-cells in the small intestine, playing a major role in regulating blood sugar levels, appetite, and overall metabolic health

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