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In the PIONEER 3 head-to-head trial, Rybelsus 14 mg delivered an HbA1c reduction of approximately -1.3% versus -0.8% for Januvia at 26 weeks a significantly greater reduction

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Ceramide reduction: Independently of weight loss, GLP-1RAs reduce ceramide levelssphingolipid intermediates involved in MASLD pathogenesis by promoting inflammation and cellular stress (Somm et al

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