how do the glp 1 drugs work agonists for diabetes GLP-1 and kidney: from physiology to pharmacology and outcomes in diabetes How GLP-1 Medications Actually Work
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Studies have shown that GLP-1 receptor agonists are effective for preventing or managing obesity
The SUMMIT trial below evaluated the effects of tirzepatide in obese patients with HFpEF
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[DOI] [PubMed] [Google Scholar] 518.Krieger J.P., Arnold M., Pettersen K.G., Lossel P., Langhans W., Lee S.J
10.1056/NEJMoa1612917 33 HomeP
Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system
