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Ex vivo glucose-stimulated insulin secretion (GSIS) in pancreatic islets After G49 treatment, pancreatic islets were incubated in KRB with 2.8 mM glucose and 0.25% BSA, pH 7.4 for 1 h at 37 C in an atmosphere of 5% CO 2

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The half-life of semaglutide (Ozempic, Wegovy, Rybelsus) is seven days

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