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Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked

The number of Americans taking a GLP-1 for weight management has increased nearly 600% over the past 6 years (FAIR Health, May 2025), making support products for those consumers more in-demand than ever