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An increased intestinal absorption of bile acids stimulates the secretion of FGF19 from intestinal enterocytes (26), and increasing circulating levels of both bile acids and FGF19 inhibit hepatic bile acid synthesis, as mentioned above
Alcohol consumption Both compounds interact with alcohol metabolism in ways that matter
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If an NSAID doesnt provide enough relief, or if side effects become problematic, your doctor may prescribe a drug belonging to a category called tumor necrosis factor (TNF) alpha-blockers

When speaking with your doctor, it may be helpful to: Share your weight management history , including previous treatments, lifestyle interventions, and any underlying conditions such as type 2 diabetes, hypertension, or sleep apnoea Ask about currently approved options , such as orlistat (available on the NHS