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Although patients may regain nearly two-thirds of their lost weight on GLP-1 RAs after cessation of the drug 16 , this early positive reinforcement may serve as an incentive to pursue a long-term, multipronged approach to combat obesity

Policy decisions on the reimbursement of tirzepatide in individual countries should be based on health technology assessments integrating long-term efficacy and safety clinical data with country-specific cost-utility analyses comparing tirzepatide with other glucose-lowering medications used in clinical practice

But for most people, it happens very, actually suddenly, and it goes away absolutely, completely despite continuation of the drug, said Marzieh Salehi, an endocrinologist and researcher studying the cross-communication between the gut and other organs at the University of Texas Health at San Antonio

Tirzepatide Once Weekly for the Treatment of Obesity SURMOUNT-1

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Association between ultra-processed food consumption and mortality among U.S