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Combining testosterone replacement with GLP-1 receptor agonists like semaglutide involves complex metabolic and hormonal interactions

GLP-1s account for 23% of first line diabetes therapy in 2025 up from 3% in 2021 Since 2019, the American Diabetes Association (ADA) has revised its Standards of Care each year to expand the role of GLP-1 receptor agonists and SGLT2 inhibitors as first-line treatments for T2D2

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Semaglutide was approved in 2017 as Ozempic for diabetes, and in 2021 as Wegovy for obesity

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