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There are many of these, and some examples include: biguanides, such as metformin (Glucophage) dipeptidyl peptidase-4 (DPP-4) inhibitors, such as sitagliptin (Januvia) glucagon-like peptide 1 (GLP-1) agonists, such as dulaglutide (Trulicity) sodium-glucose co-transporter 2 (SGLT2) inhibitors, such as canagliflozin (Invokana) sulfonylureas, such as glipizide (Glucotrol) thiazolidinediones (TZDs), such as pioglitazone (Actos) Humalog is used to help manage blood sugar levels in people with type 1 or type 2 diabetes

Heidenreich et al., 2022

Some compounding pharmacies claim to offer it, but the FDA has not approved any compounded version of retatrutide

The research showed that tirzepatide is most vulnerable to oxidative stress and basic pH conditions

Combining two GLP-1 RAs could potentially increase the risk of side effects and may not provide significant additional benefits for weight loss

Can you be allergic to semaglutide (glucagon-like peptide-1 (GLP-1) receptor agonist)?