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[] Consistent with our study, significant decreases in total cholesterol, LDL cholesterol, and free fatty acids were reported in the semaglutide group compared with the placebo group in the SUSTAIN trial, one of the major clinical trials regarding the efficacy of semaglutide in patients with T2DM
The fatty acylated co-agonist also produced a greater rate of insulin secretion compared to liraglutide during a hyperglycemic clamp in cynomolgus monkeys 40

Bloomgarden et al reported results from a meta-regression analysis of 61 clinical trials evaluating the efficacy of the five major classes of oral anti-hyperglycemic agents (11)

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