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Phentermine's sympathomimetic stimulation combined with semaglutide's direct cardiovascular effects creates compounded stress on the heart, particularly in people with existing hypertension or arrhythmia history

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Although, most participants lost weight, there was heterogenicity, that has been well-documented in obesity studies [66] and those with higher BMI above 35 experienced greater mean percentage weight loss [64]

SuNLiYXuTLiLKwongJSWDuHet alExenatide in obese or overweight patients without diabetes: a systematic review and meta-analyses of randomized controlled trials