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Native GLP-1 is cleaved within minutes by DPP-4 and has a half-life of under two minutes

Second, stable hormone levels may improve your initial response to the GLP-1 medication

1 Although GLP-1 RAs are considered to have effects on both fasting and prandial glucose control, evidence suggests that the shorter-acting agents (exenatide and liraglutide) have a greater effect on postprandial values compared to the weekly administered GLP-1 RAs

doi:10.1007/s00259-019-04409-1 151

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They activate receptors that slow down digestion, reduce appetite, and signal to the brain that you are full