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Diabetes is a complex disease that requires not only adherence to medications (including insulin regimens and oral drugs) but also to diet, physical exercise and home glucose monitoring, among others

"Muscle matters: the effects of medically induced weight loss on skeletal muscle." The Lancet Diabetes & Endocrinology 12.11 (2024): 785-787

Approval of tirzepatide (brand name Mounjaro/Zepbound), an even more efficacious medication, soon followed in 2023

For weight management, the timing may be different

Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort

Participants were randomized to receive 3 mg, 7 mg, or 14 mg of oral semaglutide or 100 mg of sitagliptin once daily