tirzepatide triple agonist Dual and Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data Novel Dual Incretin Receptor Agonists

Even small amounts of daily movement make a difference

Replacement of the C-terminal Trp-cage of exendin-4 with a fatty acid improves therapeutic utility

NICE announced that final guidance on tirzepatide will be released by October 2023, and tirzepatide will be available in the NHS within 90 days

Even Phe could be considered as a potential replacement, and Lys from exenatide/CY-5 also seems feasible

Comparing both to semaglutide (Ozempic/Wegovy) Any conversation about retatrutide versus Mounjaro would be incomplete without placing both in the context of semaglutide, the drug that started the GLP-1 weight loss revolution

36 The attachment of long fatty acids relayed by a carboxylic linkage leaves the affinity and activity almost unaffected