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We know that without a better cost management structure, most employers will be unable to cover GLP-1 benefits for weight loss, despite the extraordinary efficacy of the medications in reducing obesity

Common side effects include: Nausea and vomiting, especially at the start of treatment Gastrointestinal discomfort, such as bloating, diarrhea, or constipation Injection site reactions like redness, swelling, or itching Loss of lean muscle mass along with fat loss Dysesthesia, which includes tingling and skin sensitivity, is reported in as many as 20.9% of patients on higher doses

In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

Abrupt cessation of Adderall can cause withdrawal symptoms and rebound ADHD symptoms, while stopping semaglutide may lead to loss of glycemic control or weight regain

How soon will I start to notice results

The results of this rodent study showed superior glycemic control effects compared to cotadutide and liraglutide with greater weight loss compared to liraglutide, but similar to the cotadutide [70]